The following benefits may be found using Meratrim Platinum+
Scientific Studies on Ingredients in MeraTrim Platinum+
- Non-stimulant metabolism booster.ⱡ∆
- Modulates the accumulation of fat while simultaneously increasing fat burning.ⱡ∆
- Reduces the expression of the peroxisome proliferator-activated receptor gamma (PPAR) hormone receptor. PPAR induces adipocyte-specific genes involved in the formation and growth of fat cells. Translation: reduction in the development/increase of fat cell size.ⱡ∆
- Reduces the expression of adipocyte differentiation related protein (ADRP). This is a signaling protein which facilitates the uptake of fatty acids to form lipid droplets and adipocyte differentiation. Translation: reduces the formation of “solid” fat and allows fatty acids to continue to circulate in blood, which may be beneficial in other applications where energy is needed.ⱡ∆
- Reduces the expression of cluster of differentiation 36 (CD36)—a trans-membrane receptor that facilitates fatty acid uptake by adipocytes. Translation: prevents/reduces fatty acid uptake for storage.ⱡ∆
- Reduces perilipin expression. Perilipins are adipocyte proteins that are localized at the surface of the lipid droplet and inhibit fat break down by restricting access of lipase to the lipid droplet. Translation: helps fat to break apart.ⱡ∆
- Elevates norepinephrine levels and controls thermogenesis.ⱡ∆
- Fat transport and mitochondrial oxidation of long-chain fatty acids.ⱡ∆
- Improves carbohydrate metabolism.ⱡ∆
1) MeraTrim™ is a proprietary plant extract blend for weight management derived from two plants—Sphaeranthus indicus flower heads and Garcinia mangostana fruit rind. Each plant contributes an essential part to MeraTrim’s ability to affect multiple pathways involved in fat cell formation and breakdown. MeraTrim (400 mg twice a day) was shown in two independent, randomized, double-blind, placebo-controlled clinical studies to significantly reduce body weight, BMI, waist and hip circumference after two weeks. The studies also showed increases in Adiponectin (in the blood) and reductions in fasting blood glucose indicating that there was an increase in fatty acid utilization. Pooled data from these two studies was also analyzed and demonstrated that MeraTrim reduces body weight, waist, and hip circumference after two weeks of supplementation. Toxicological studies on MeraTrim demonstrate a wide margin of safety and no major adverse events have been reported.
2) Recent data from human studies indicate that the consumption of green tea and green tea extracts may help reduce body weight, mainly body fat, by increasing post-meal thermogenesis and fat oxidation. Additional findings from various studies suggest that EGCG alone has the potential to increase fat oxidation and may help contribute to body fat reduction that is found with green tea consumption.
3) Study data suggest that L-carnitine may induce subtle changes in substrate handling in metabolically active tissues when fatty-acid availability is increased. Furthermore, L-carnitine supplementation had positive effects and significantly attenuated biochemical markers of purine metabolism (i.e., hypoxanthine, xanthine oxidase), free radical formation (malondialdehyde), muscle tissue disruption (myoglobin, creatine kinase), and muscle soreness after physical exertion. While physical performance metrics such as strength and power were not shown to improve during the testing, the findings suggest that L-carnitine supplementation can reduce chemical damage to tissues after exercise and optimize the processes of muscle tissue repair and remodeling. Thus L-carnitine may prove to be effective in improving overall long-term performance while improving fat utilization.
List of References
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Rodriguez, S.K., et al., (2005) "Green tea catechin, epigallocatechin-3-gallate, inhibits vascular endothelial growth factor angiogenic signalling by disrupting the formation of a receptor complex." Int J Cancer. 10.
Singh, S.K., et al., "An Antimicrobial Principle from Sphaeranthus indicus L. (Family Compositae)" Int J Crude Drug Res. 1988;26:235–9.
Sohoni, J.S., et al., "A new eudesmenolide and 2-hydroxycostic acid from Spharanthus indicus Linn. x-ray molecular structure of 4-alpha, 5-alpha-epoxy-7-alpha-hydroxyeudesmanolide." J Chem Soc Perkin 1. 1988;2:157–60
Stern, J.S., et al., "Efficacy and tolerability of a novel herbal formulation for weight management." Obesity. 2013 May;21(5):921-7.
Suksamrarn, S., et al., "Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana."
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Yadava, R.N., and Kumar, S. "A novel isoflavone glycoside from the leaves of Spharanthus indicus." Fitoterapia. 1999;70:127–9.
Yoshikawa, M., et al., "Antioxidant constituents from the fruit hulls of mangosteen (Garcinia mangostana L.) originating in Vietnam," Yakugaku Zasshi = Journal of the Pharmaceutical Society of Japan (1994) 114(2): 129-133.
What has the media and the scientific community so excited over Raspberry Ketones?
Featured on America’s top medical shows and highly touted by nutritional experts, raspberry ketones and green coffee bean extract appear to be a new breed of supplements that don’t require people to do anything different when taking them—and as a result, are causing a consumer buying frenzy!
Why is that? Because the most recent clinical studies on raspberry ketones and green coffee bean followed a group of 16 adults who supplemented with green coffee bean for only 12 weeks. Over the course of the study, the subjects lost an average of 17 pounds each—this was 10.5% of their overall body weight and 16% of their overall body fat!‡ There were no side effects reported. This is very exciting information and one reason America’s most popular doctor thinks raspberry ketones and green coffee bean could be the most effective weapons at potentially reversing the overweight epidemic in our country.
Scientific Summary on Raspberry Ketone Studies
In fact, in one study by Morimoto, et al. (2005), raspberry ketones were fed at various dosages to growing mice for 10 weeks. Mice were then fed a high-fat diet (to induce obesity) plus one or two percent raspberry ketone (- 10,000 mg per kg body weight). Those given raspberry ketone gained less bodyfat than control animals. Plus, raspberry ketone also decreased the weights of the liver and visceral adipose tissues—that is, fat around the organs. Raspberry ketone was also shown to increase brown adipose tissue thermogenesis (burning calories through heat), the end result of which is increased fat burning.
After the full 11 week study it was determined that raspberry ketone:
- Reduces fatty build up in liver.
- Raspberry ketones did in fact stop the high-fat-diet-induced elevations in body weight and the weights of the liver and visceral adipose tissues.
- Raspberry Ketone also decreased these weights and hepatic triacylglycerol content after they had been increased by a high-fat diet.
- Raspberry Ketone significantly increased norepinephrine induced lipolysis associated with the translocation of hormone-sensitive lipase.
In summary, it was determined that raspberry ketones can help with the breakdown or destruction of fats (increased lipolysis), decrease liver fat, speed up metabolism, and prevent an increase in body weight. The results revealed that the addition of raspberry ketones help reverse the weight gain induced by the high-fat diet and protect against the buildup of fat in the liver.
- Nagendran MV. Effect of Green Coffee Bean Extract (GCE), High in Chlorogenic Acids, on Glucose Metabolism. Poster presentation number: 45-LB-P. Obesity 2011, the 29th Annual Scientific Meeting of the Obesity Society. Orlando, Florida. October 1-5, 2011. Am J Med. 2008 Jun;121(6):519-24.
- Cancer Prev Res (Phila). 2011 Jun 22. J Agric Food Chem. 2010 Apr 14;58(7):4141-4. Ethnopharmacol. 2010 Jul 6;130(1):93-7.
- Cell Biochem Funct. 2008 Apr;26(3):320-8. J Nutr Sci Vitaminol (Tokyo). 2007 Apr;53(2):166-73.
- J Nutr Biochem. 2006 Jan;17(1):63-71.
- Food and Cosmetics Toxicology 8 (4):349–358.
- Morimoto C, el al., (2005). Life Sci. 77 (2): 194–204.
Emotional Eaters May Benefit from the power of Hydroxy Citric Acid
A recent study, featured on America’s most trusted doctor's television show, featured the use of hydroxycitric acid (HCA) extract from Garcinia cambogia with 60 obese people , who were placed on a calorie-reduced diet combined with HCA for eight weeks, and lost an average of 14 pounds (compared to 6.1 pounds in the placebo group). Participants in the study reported no side effects. Other research has indicated that even with no changes to diet or exercise, weight loss is still experienced.
This study quickly got the attention of the media and America’s most trusted doctor
Garcinia cambiogia fruit naturally contain a powerful compound called Hydroxycitric Acid (HCA) which is the active weight-loss compound found in Garcinia Trim.
Scientific Summary on Hydroxycitric Acid Studies
In another recent study published in the Diabetes, Obesity, and Metabolism journal, scientists used Garcinia cambogia with 60% (GCA®) to study its weight loss effects. What they found was nothing short of remarkable. It caused significant weight loss, reduces emotional urges to eat, as well as promoting health factors such as lower cholesterol (LDL), low-density lipoproteins, triglycerides, and serum leptin levels. You can see the full clinical study by Clicking here.
Garcinia cambogia with 60% Hydroxycitri Acid (GCA®)
It's important to note that it was ONLY Garcinia cambogia that contained 60% Hydroxycitric Acid (GCA®) used in the study, which is what is found in Garcinia Trim™. Not a cheaper imported extract. Garcinia Trim™, from BioGenetic Laboratories, contains 60% Hydroxycitric Acid (GCA®), as verified by independent laboratory analysis, which is the key to weight loss in Garcinia cambogia, while other products likely contain much lower contents, between 30-50%.
- Igho Onakpoya, Shao Kang Hung, Rachel Perry, Barbara Wider, and Edzard Ernst, “The use of Garcinia Extract (Hydroxycitric Acid) as a weight loss supplement: A Systematic Review and Meta-Analysis of Randomised Clinical Trials”. Journal of Obesity, Volume 2011 (2011), Article ID 509038, doi:10.1155/2011/509038.
Scientific Summary on Green Coffee Bean Studies
The most recent clinical studies on green coffee bean (Nagendran, et al., 2011), and raspberry ketones followed a group of 16 adults who supplemented with green coffee bean for only 12 weeks. Over the course of the study, the subjects lost an average of 17 pounds each—this was 10.5% of their overall body weight and 16% of their overall body fat!‡ There were no side effects reported. This is very exciting information and one reason America’s most popular doctor thinks green coffee bean and raspberry ketones could be the most effective weapons at potentially reversing the overweight epidemic in our country.
The good news is there were no side effects reported, and they didn’t have to change their lifestyles, such as dieting or exercising. You heard that right— clinical studies were preformed without requiring diet or exercise from participants. However, combined with our diet and exercise protocol (free with every purchase, inside the box), you can take your weight loss even further for optimal results.
- Nagendran MV. Effect of Green Coffee Bean Extract (GCE), High in Chlorogenic Acids, on Glucose Metabolism. Poster presentation number: 45-LB-P. Obesity 2011, the 29th Annual Scientific Meeting of the Obesity Society. Orlando, Florida. October 1-5, 2011.
- Am J Med. 2008 Jun;121(6):519-24. Cancer Prev Res (Phila). 2011 Jun 22. J Agric Food Chem. 2010 Apr 14;58(7):4141-4. Ethnopharmacol. 2010 Jul 6;130(1):93-7.
- Cell Biochem Funct. 2008 Apr;26(3):320-8.
- J Nutr Sci Vitaminol (Tokyo). 2007 Apr;53(2):166-73.
- J Nutr Biochem. 2006 Jan;17(1):63-71.
- Food and Cosmetics Toxicology 8 (4): 349–358. Morimoto C, el al., (2005).
- Life Sci. 77 (2): 194–204.
Can CLA Help You Lose Belly Fat?
Three new published research studies reveal that losing weight and reducing body fat, especially around the waist, could be as easy as taking a daily CLA supplement... and now combined with a new weight-loss blend YGD™, suggest it may make the weight loss easier and more profound.
STUDY SUMMARY OF CLA #1 : The US study set out to investigate conjugated linoleic acid (CLA, naturally derived from safflower oil) and included 40 overweight adults. For the duration of the study, participants took either CLA or a placebo (a pill that contains no active ingredients). During this time, the participants were asked not to change their diets. The researchers found those taking CLA lost significantly more body fat and weight than those taking the placebo. That’s not all. During November and December (the US holiday season), those participants in the study taking the placebo gained more weight than those taking CLA.
STUDY SUMMARY OF CLA #2: More recently, at the Experimental Biology medical conference, scientists presented a fascinating study in which another group was supplemented with CLA or CLA plus guarana. After only 6 weeks, both groups showed a substantial reduction in fat mass. In the CLA-only group, the decrease in fat mass was due to a reduction in fat-cell size, without a change in fat-cell number. In the CLA plus guarana group, both fat-cell size and number were reduced by 50% over the CLA-only group. (FASEB 2002).
STUDY SUMMARY OF CLA #3: A study recently published in the International Journal of Obesity concluded that CLA reduces abdominal fat among men classified as abdominally overweight. This double-blind, randomized, placebo-controlled trial observed 25 men with significant abdominal fat for four weeks. At the conclusion of the study, the participants taking CLA lost an average of 1.4 cm in waist circumference (abdominal diameter) after only four weeks. What’s interesting is that none of the study participants changed their eating or exercise habits during the trial period.
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AFRICAN MANGO SUPER FRUIT DIET™
African Mango Super Fruit™ Diet is the only weight-loss pill that combines the world’s most popular super fruits (Lychee, Acai, Resveratrol, Maquii berries) with clinically tested, patented form African Mango
Known scientifically as Irvingia gabonensis, African Mango is a rare cousin to the common mangoes found in North and South America, though this form is a dietary staple in the West African country of Cameroon. Extracts of this super fruit are used in traditional medicines, and because of recent scientific evidence, has been coined “the miracle in your medicine cabinet,” by one of America’s most popular doctors because of its powerful weight-loss and health benefits.
Scientific Summary on African Mango Studies
Two landmark studies in particular. In the first four-week-long study, published in the prestigious Journal Lipids in Health and Disease, 40 overweight people were given either IGOB131® African Mango or a comparable amount of oat bran 30 minutes before meals, in conjunction with a low-fat diet. Both groups ate the same. At the end of this four-week study, those receiving IGOB131 African Mango lost about 5.6% of their body weight, whereas those in the placebo group lost only about 1% of their body weight.
In yet another groundbreaking clinical study on IGOB131® African Mango, a 10-week study, published in 2009 in the journal, Lipids in Health and Disease, 102 healthy overweight men and women were followed for 10 weeks. Subjects were split into either a placebo group or a group that received daily IGOB131® African Mango. In those receiving the IGOB131® African Mango, body weight, body fat, and waist circumference had decreased significantly more than in the placebo group.
Those subjects receiving the IGOB131® African Mango lost 28 pounds, whereas the placebo group lost only about one pound. Talk about a weight-loss powerhouse! Equally exciting, LDL cholesterol (bad cholesterol), total cholesterol, blood glucose, and C-reactive protein (a critical heart-health marker) were also lower in those who received the African Mango.
Patented IGOB131® , Contained in African Mango Super Fruit™
The patented form of African Mango extract is named IGOB131®, and it is important you keep an eye out for this specifically named form. We are telling you this because if you try looking for African Mango (Irvingia gabonensis) in other weight-loss supplements (than our African Mango Super Fruit Diet pill), this is the ingredient that the scientific research was actually conducted on. Other, generic forms of African Mango extracts and products may not have the same effect, and you cannot be guaranteed you are even getting real African Mango. So buyer beware! You can be assured, however, that with our product you are guaranteed to receive the patented African Mango extract, IGOB131®, and is certified the purest and most effective African Mango on the market.
- Natural Medicines Comprehensive Database. Stockton, Calif, USA: Therapeutic Research Faculty; Irvingia Gabonensis. Updated (periodically).
- Ngondi JL, et al., Lipids Health Dis. 2009 Mar 2;8:7.
- Ngondi JL, et al., Lipids Health Dis. 2005; 4, article 12.
- Oben JE, et al., Lipids Health Dis. 2008 Mar 31;7:12.
- The Oz Show®, "Miracles in Your Medicine Cabinet," September 13, 2010.
- Tchoundjeu, Z. & Atangana, A.R., 2007. Irvingia gabonensis (Aubry-Lecomte ex O’Rorke) Baill. [Internet] Record from Protabase. van der Vossen, H.A.M. & Mkamilo, G.S. (Editors). PROTA (Plant Resources of Tropical Africa / Ressources végétales de l’Afrique tropicale), Wageningen, Netherlands. http://database.prota.org/search.htm . Accessed 12 July 2011.
- Dr Ingrid van Heerden "African Mango—Weight Loss Wonder Fruit?" http://www.health24.com/dietnfood/Weight_Centre/15-51-2974,64016.asp July 11, 2011.
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hCG ACTIVATOR™, the weight-loss breakthrough that compliments America’s most popular low calorie diet”
hCG Activator contains absolutely no hCG drug, no hormones, and it is a natural combination of ingredients that serve as a healthy alternative to hormone administration. hCG Activator does not claim to be a "miracle pill" but instead uses an exclusive dietary formula and medically researched dieting protocol based on Dr. Simeons’ diet.
hCG stands for human chorionic gonadotropin (pronounced Core-eon-ik Go-na-do-tro-pin). It is a hormone produced naturally by men and women (and substantially higher while a woman is pregnant). It is normally administered by a medical doctor in daily, painful injections that cost about $400 to $600 per month. When used in conjunction with the official 500-calorie hCG very low-calorie diet, it may help your body exert and use more stored energy.
Scientific Summary on Studies of the Key Ingredients in hCG Activator
There are over 47 clinical studies documenting the healthy, weight-loss and psychological effects of the key ingredients inside hCG Activator. These studies are listed below in the “Additional Supporting Research” section. And, equally important, these studies reported the ingredients were safe to use.
Natural “Appetite-Control” from Saffron Extract
The exciting news is a natural appetite regulator, a natural plant extract, has been identified that operates at the neurochemical level to help provoke “satiety”—the feeling of being full. This unique extract is derived from saffron, prized for centuries not only as a spice but also as a mood enhancer in traditional cultures.
In one of the most compelling findings on emotional eating, Dutch researchers reported that compulsive eating can result from a common gene variant for the molecule that transports serotonin, one of the body’s primary “mood regulators.” People carrying this gene suffer from lower serotonin activity, predisposing them to depression and anxiety, especially under stress. In fact, the Dutch study revealed that teens carrying this gene indulge in emotional eating at a significantly higher rate.
More interesting to Bourges and his team of researchers were the significant declines in reported feelings of hunger between meals, an effect that persisted until dinner in 25% of women taking the saffron extract. In contrast, 50% of placebo recipients reported an increased desire to eat. By the end of the study, 100% of women in the saffron group reported successful reduction in daily between-meal eating, as opposed to controls, who saw no improvement.
With these impressive findings, Bourges and his team launched a full-scale clinical trial of 60 slightly overweight women 25 – 45 years old. This time, they focused specifically on women who reported frequent, anxiety-related between-meal and after-dinner snacking. Their goal was to test the saffron’s psychotropic (“mood-altering”) potential in helping to reduce the anxiety behind compulsive eating.
Once again, weight loss was relatively modest: over one pound at the two-week mark versus a slight gain in the placebo group. By eight weeks, the average weight loss had increased, reaching just over two pounds, with 26% of subjects losing up to 11 pounds. Interestingly, women taking saffron saw a significant reduction in thigh circumference.
It was the psychological effect reported in the saffron group that again proved most compelling, especially given the susceptibility to compulsive between-meal consumption. The women reported a significant reduction in feelings of hunger before meals. They also experienced a significantly diminished “need” to snack between meals. The favorable alteration in these urges had tangible results. At baseline, women in both groups had reported an average of about 12 snacking episodes per week. After eight weeks, the average was just six episodes per week in the saffron group—a 50% reduction.
These results validated the French team’s hypothesis: something about this particular saffron extract was working to control the compulsion to eat in this vulnerable sample of women. They reported that “subjects in the saffron group felt significantly more alert and energetic than the placebo group”—feelings that correspond with emergence from sub-clinical depression and anxiety. As noted above, depression and anxiety are the foundation for compulsive eating.
Supports Healthy Body Mass and Composition
America’s looming overweight epidemic has encouraged scientists to seek new agents that promote healthy body weight and composition. Certain spicy foods and herbal drinks have long been used as weight-management tools because of their purported ability to promote thermogenesis or satiety.
During the past decade, green tea has received particular attention for its role in promoting healthy weight management. Its weight-control effects have been studied extensively in cell, animal, and human studies. In all, there have been over 1,500 published studies in the last five years alone. Laboratory and animal models suggest that green tea, green tea polyphenols known as catechins, and green tea’s principal catechin, EGCG, may work to promote healthy weight management by:
- reducing fat cell proliferation
- decreasing body and fat mass
- inhibiting fat absorption
- lowering blood levels of triglycerides, cholesterol, glucose, and insulin.
At the same time, green tea has been found to increase the oxidation (breakdown) of fats. Human studies suggest that green tea consumption is associated with decreased body mass and body fat.
- Gout, B., et al., “Saffron, a Crocus sativus L extract, reduces snacking and increases satiety in a randomized placebo-controlled study of mildly overweight, healthy women.” Nutrition Research. 2010 May;30(5):305-13.
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- “Pounds & Inches: A New Approach to Obesity”; Simeons, Dr. ATW, Salvator Mundi International Hospital 00152 - Rome Viale Mura Gianicolensi, 77.
- Wolfram S, Wang Y, Thielecke F. Anti-obesity effects of green tea: from bedside to bench. Mol Nutr Food Res. 2006 Feb;50(2):176-87.
- Dulloo AG, Seydoux J, Girardier L, Chantre P, Vandermander J. Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity. Int J Obes Relat Metab Disord. 2000 Feb;24(2):252-8.
- Shixian Q, Vancrey B, Shi J, Kakuda Y, Jiang Y. Green tea extract thermogenesis-induced weight loss by epigallocatechin gallate inhibition of catechol-o-methyltransferase. J Med Food. 2006;9(4):451-8.
- Juhel C, Armand M, Pafumi Y, et al. Green tea extract (AR25) inhibits lipolysis of triglycerides in gastric and duodenal medium in vitro. J Nutr Biochem. 2000 Jan;11(1):45-51.
Hsu TF, Kusumoto A, Abe K, et al. Polyphenol-enriched oolong tea increases fecal lipid excretion. Eur J Clin Nutr. 2006 Nov;60(11):1330-6.
- Klaus S, Pultz S, Thone-Reineke C, Wolfram S. Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation. Int J Obes (Lond). 2005 Jun;29(6):615-23.
- High Bioavailability of a Standardized Green Tea Extract. NUTRAfoods 7(4) 21-28 (2008).
Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr 1999; 70: 1040-5.
- Anti-obesity effects of green tea: from bedside to bench. Mol Nutr Food Res. 2006 Feb; 50(2):176-87.
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Additional Supporting Research for green tea (Camellia sinesis) in particular to health benefits:
- Belza A, Toubro S, Astrup A. The effect of caffeine, green tea and tyrosine on thermogenesis and energy intake. Eur J Clin Nutr. 2007; [Epub ahead of print].
- Bettuzzi S, Brausi M, Rizzi F, Castagnetti G, Peracchia G, Corti A. Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res. 2006;66(2):1234-40.
- Borrelli F, Capasso R, Russo A, Ernst E. Systematic review: green tea and gastrointestinal cancer risk. Aliment Pharmacol Ther Mar 1, 2004;19(5):497-510.
- Boschmann M, Thielecke F. The effects of epigallocatechin-3-gallate on thermogenesis and fat oxidation in obese men: a pilot study. J Am Coll Nutr. 2007;26(4):389S-395S.
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